3RK3
 
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3RL0
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3RK2
 | | Truncated SNARE complex | | 分子名称: | CALCIUM ION, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | 著者 | Kuemmel, D, Reinisch, K.M. | | 登録日 | 2011-04-17 | | 公開日 | 2011-07-27 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Complexin cross-links prefusion SNAREs into a zigzag array.
Nat.Struct.Mol.Biol., 18, 2011
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7ZTY
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9HTH
 | | Crystal structure of the fused, cysteine-less Aes123 PolB1 split intein (with S1A, N159A mutations) | | 分子名称: | DNA-directed DNA polymerase | | 著者 | Fitzian, K, Yilmaz, Z, Humberg, C, Mootz, H.D, Kuemmel, D. | | 登録日 | 2024-12-19 | | 公開日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1.378 Å) | | 主引用文献 | A cysteine-less and ultra-fast split intein rationally engineered from being aggregation-prone to highly efficient in protein trans-splicing.
Nat Commun, 16, 2025
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5LDD
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8CPO
 | | Crystal structure of the PolB16_OarG intein variant S1A, N183A, C111A, C165A | | 分子名称: | PolB16 Intein Cys-less | | 著者 | Kattelmann, S, Pasch, T, Mootz, H.D, Kuemmel, D. | | 登録日 | 2023-03-03 | | 公開日 | 2023-05-17 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins.
Chem Sci, 14, 2023
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8CCK
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8CCJ
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8CCM
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8CCL
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7ZU0
 | | HOPS tethering complex from yeast | | 分子名称: | E3 ubiquitin-protein ligase PEP5, Vacuolar membrane protein PEP3, Vacuolar morphogenesis protein 6, ... | | 著者 | Shvarev, D, Schoppe, J, Koenig, C, Perz, A, Fuellbrunn, N, Kiontke, S, Langemeyer, L, Januliene, D, Schnelle, K, Kuemmel, D, Froehlich, F, Moeller, A, Ungermann, C. | | 登録日 | 2022-05-11 | | 公開日 | 2022-09-28 | | 最終更新日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.
Elife, 11, 2022
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7QLA
 | | Structure of the Rab GEF complex Mon1-Ccz1 | | 分子名称: | Ccz1, Vacuolar fusion protein MON1 | | 著者 | Klink, B.U, Herrmann, E, Antoni, C, Langemeyer, L, Kiontke, S, Gatsogiannis, C, Ungermann, C, Raunser, S, Kuemmel, D. | | 登録日 | 2021-12-20 | | 公開日 | 2022-02-09 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | | 主引用文献 | Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8C7G
 | | Drosophila melanogaster Rab7 GEF complex Mon1-Ccz1-Bulli | | 分子名称: | Caffeine, calcium, zinc sensitivity 1, ... | | 著者 | Schaefer, J, Herrmann, E, Kuemmel, D, Moeller, A. | | 登録日 | 2023-01-15 | | 公開日 | 2023-05-17 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structure of the metazoan Rab7 GEF complex Mon1-Ccz1-Bulli.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7P9E
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6LTW
 | | Crystal structure of Apo form of I122A/I330A variant of S-adenosylmethionine synthetase from Cryptosporidium hominis | | 分子名称: | MAGNESIUM ION, PHOSPHATE ION, S-adenosylmethionine synthase | | 著者 | Singh, R.K, Michailidou, F, Rentmeister, A, Kuemmel, D. | | 登録日 | 2020-01-23 | | 公開日 | 2020-10-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions.
Angew.Chem.Int.Ed.Engl., 60, 2021
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6LTV
 | | Crystal Structure of I122A/I330A variant of S-adenosylmethionine synthetase from Cryptosporidium hominis in complex with ONB-SAM (2-nitro benzyme S-adenosyl-methionine) | | 分子名称: | MAGNESIUM ION, S-adenosylmethionine synthase, TRIPHOSPHATE, ... | | 著者 | Singh, R.K, Michailidou, F, Rentmeister, A, Kuemmel, D. | | 登録日 | 2020-01-23 | | 公開日 | 2020-10-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7P9D
 | | Crystal structure of Chlamydomonas reinhardtii NADPH Dependent Thioredoxin Reductase 1 domain | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Thioredoxin reductase | | 著者 | Singh, R.K, Marchetti, G.M, Hippler, M, Kuemmel, D. | | 登録日 | 2021-07-27 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structural analysis revealed a novel conformation of the NTRC reductase domain from Chlamydomonas reinhardtii.
J.Struct.Biol., 214, 2021
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8CCI
 | | Crystal structure of Mycobacterium smegmatis thioredoxin reductase | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Fuesser, F.T, Koch, O, Kuemmel, D. | | 登録日 | 2023-01-27 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Novel starting points for fragment-based drug design against mycobacterial thioredoxin reductase identified using crystallographic fragment screening.
Acta Crystallogr D Struct Biol, 79, 2023
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6ZGQ
 | | AceL NrdHF class 3 split intein GSH linked splice inactive variant - C124A, N146A | | 分子名称: | AceL NrdHF-1-1 Intein, IODIDE ION | | 著者 | Hoffmann, S, Mootz, H.D, Kuemmel, D, Singh, R. | | 登録日 | 2020-06-19 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Biochemical and Structural Characterization of an Unusual and Naturally Split Class 3 Intein.
Chembiochem, 22, 2021
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7A0N
 | | Structure of TSC1 NTD and linker domain | | 分子名称: | Uncharacterized protein,Uncharacterized protein | | 著者 | Fitzian, K, Kuemmel, D. | | 登録日 | 2020-08-10 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
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7A0M
 | | TSC1 N-terminal domain | | 分子名称: | SULFATE ION, TSC1 N-terminal domain | | 著者 | Zech, R, Kiontke, S, Kuemmel, D. | | 登録日 | 2020-08-10 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
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7P84
 | | Crystal structure of L147A/I351A variant of S-adenosylmethionine synthetase from Methanocaldococcus jannaschii in complex with ONB-SAM (2-nitro benzyme S-adenosyl-methionine) | | 分子名称: | MAGNESIUM ION, S-adenosylmethionine synthase, TRIPHOSPHATE, ... | | 著者 | Herrmann, E, Peters, A, Cornelissen, N.V, Rentmeister, A, Kuemmel, D. | | 登録日 | 2021-07-21 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.054 Å) | | 主引用文献 | Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases.
Chembiochem, 23, 2022
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7P8M
 | | Crystal structure of L147A/I351A variant of S-adenosylmethionine synthetase from Methanocaldococcus jannaschii in complex with DMNB-SAM (4,5-dimethoxy-2-nitro benzyme S-adenosyl-methionine) | | 分子名称: | 4,5-dimethoxy-2-nitro benzyme S-adenosyl-methionine, MAGNESIUM ION, S-adenosylmethionine synthase, ... | | 著者 | Herrmann, E, Peters, A, Cornelissen, N.V, Rentmeister, A, Kuemmel, D. | | 登録日 | 2021-07-23 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases.
Chembiochem, 23, 2022
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7P82
 | | Crystal structure of apo form L147A/I351A variant of S-adenosylmethionine synthetase from Methanocaldococcus jannaschii | | 分子名称: | S-adenosylmethionine synthase | | 著者 | Herrmann, E, Peters, A, Cornelissen, N.V, Rentmeister, A, Kuemmel, D. | | 登録日 | 2021-07-21 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.042 Å) | | 主引用文献 | Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases.
Chembiochem, 23, 2022
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