6GAV
 
 | | Extremely 'open' clamp structure of DNA gyrase: role of the Corynebacteriales GyrB specific insert | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA gyrase subunit B,DNA gyrase subunit A | | Authors: | Petrella, S, Capton, E, Alzari, P.M, Aubry, A, MAyer, C. | | Deposit date: | 2018-04-12 | | Release date: | 2019-02-20 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity.
Structure, 27, 2019
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6GAU
 | | Extremely 'open' clamp structure of DNA gyrase: role of the Corynebacteriales GyrB specific insert | | Descriptor: | DNA gyrase subunit B,DNA gyrase subunit A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Petrella, S, Capton, E, Alzari, P.M, Aubry, A, Mayer, C. | | Deposit date: | 2018-04-12 | | Release date: | 2019-02-20 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity.
Structure, 27, 2019
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2WKX
 | | Crystal structure of the native E. coli zinc amidase AmiD | | Descriptor: | CHLORIDE ION, GLYCEROL, N-ACETYLMURAMOYL-L-ALANINE AMIDASE AMID, ... | | Authors: | Petrella, S, Kerff, F, Herman, R, Genereux, C, Pennartz, A, Sauvage, E, Joris, B, Charlier, P. | | Deposit date: | 2009-06-18 | | Release date: | 2010-01-12 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Specific Structural Features of the N-Acetylmuramoyl-L-Alanine Amidase Amid from Escherichia Coli and Mechanistic Implications for Enzymes of This Family.
J.Mol.Biol., 397, 2010
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3DW0
 | | Crystal structure of the class A carbapenemase KPC-2 at 1.6 angstrom resolution | | Descriptor: | Class A carbapenemase KPC-2 | | Authors: | Petrella, S, Ziental-Gelus, N, Mayer, C, Jarlier, V, Sougakoff, W. | | Deposit date: | 2008-07-21 | | Release date: | 2008-07-29 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France.
Antimicrob.Agents Chemother., 52, 2008
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3PL1
 | | Determination of the crystal structure of the pyrazinamidase from M.tuberculosis : a structure-function analysis for prediction resistance to pyrazinamide. | | Descriptor: | FE (II) ION, PYRAZINAMIDASE/NICOTINAMIDASE PNCA (PZase) | | Authors: | Petrella, S, Gelus-Ziental, N, Mayer, C, Sougakoff, W. | | Deposit date: | 2010-11-12 | | Release date: | 2011-01-12 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal Structure of the Pyrazinamidase of Mycobacterium tuberculosis: Insights into Natural and Acquired Resistance to Pyrazinamide.
Plos One, 6, 2011
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2BH7
 | | Crystal structure of a SeMet derivative of AmiD at 2.2 angstroms | | Descriptor: | N-ACETYLMURAMOYL-L-ALANINE AMIDASE, SULFATE ION, ZINC ION | | Authors: | Petrella, S, Herman, R, Sauvage, E, Genereux, C, Pennartz, A, Joris, B, Charlier, P. | | Deposit date: | 2005-01-07 | | Release date: | 2006-06-22 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Specific Structural Features of the N-Acetylmuramoyl-L-Alanine Amidase Amid from Escherichia Coli and Mechanistic Implications for Enzymes of This Family.
J.Mol.Biol., 397, 2010
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2BH0
 | | Crystal structure of a SeMet derivative of EXPA from Bacillus subtilis at 2.5 angstrom | | Descriptor: | YOAJ | | Authors: | Petrella, S, Herman, R, Sauvage, E, Filee, P, Joris, B, Charlier, P. | | Deposit date: | 2005-01-06 | | Release date: | 2006-06-28 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure and Activity of Bacillus Subtilis Yoaj (Exlx1), a Bacterial Expansin that Promotes Root Colonization.
Proc.Natl.Acad.Sci.USA, 105, 2008
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1W7F
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3C5A
 | | Crystal structure of the C-terminal deleted mutant of the class A carbapenemase KPC-2 at 1.23 angstrom | | Descriptor: | CITRIC ACID, Class A carbapenemase KPC-2 | | Authors: | Petrella, S, Ziental-Gelus, N, Mayer, C, Jarlier, V, Sougakoff, W. | | Deposit date: | 2008-01-31 | | Release date: | 2008-08-05 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.23 Å) | | Cite: | Genetic and structural insights into the dissemination potential of the extremely-broad-spectrum class A {beta}-lactamase (EBSBL) KPC-2 identified in two strains of Escherichia coli and Enterobacter cloacae isolated from the same patient in France
ANTIMICROB.AGENTS CHEMOTHER., 2008
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4G3N
 | | Mycobacterium tuberculosis gyrase type IIA topoisomerase C-terminal domain at 1.4 A resolution | | Descriptor: | DNA gyrase subunit A | | Authors: | Darmon, A, Piton, J, Petrella, S, Aubry, A, Mayer, C. | | Deposit date: | 2012-07-15 | | Release date: | 2013-08-07 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes.
Biochem.J., 455, 2013
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8S7O
 | | M. tuberculosis gyrase holocomplex with 150 bp DNA and BDM71403 | | Descriptor: | 6-[[2-[1-(6-methoxy-1,5-naphthyridin-4-yl)-1,2,3-triazol-4-yl]ethylamino]methyl]-4H-1,4-benzothiazin-3-one, DNA (5'-D(*CP*CP*GP*GP*AP*AP*GP*GP*GP*GP*TP*AP*AP*TP*AP*CP*T)-3'), DNA gyrase subunit A, ... | | Authors: | Gedeon, A, Yab, E, Dinut, A, Sadowski, E, Capton, E, Dreneau, A, Gioia, B, Piveteau, C, Djaout, K, Lecat, E, Wehenkel, A.M, Gubellini, F, Mechaly, A, Alzari, P.M, Deprez, B, Baulard, A, Aubry, A, Willand, N, Petrella, S. | | Deposit date: | 2024-03-04 | | Release date: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | M. tuberculosis gyrase holocomplex with 150 bp DNA and BDM71403
To Be Published
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3M4I
 | | Crystal structure of the second part of the Mycobacterium tuberculosis DNA gyrase reaction core: the TOPRIM domain at 1.95 A resolution | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA gyrase subunit B | | Authors: | Piton, J, Petrella, S, Aubry, A, Mayer, C. | | Deposit date: | 2010-03-11 | | Release date: | 2010-09-29 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
Plos One, 5, 2010
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6Z03
 | | DNA Topoisomerase | | Descriptor: | DNA topoisomerase I | | Authors: | Takahashi, T.S, Gadelle, D, Forterre, P, Mayer, C, Petrella, S. | | Deposit date: | 2020-05-07 | | Release date: | 2021-11-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states.
Nat Commun, 13, 2022
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6Z01
 | | DNA Topoisomerase | | Descriptor: | CHLORIDE ION, DNA topoisomerase I | | Authors: | Takahashi, T.S, Gadelle, D, Forterre, P, Mayer, C, Petrella, S. | | Deposit date: | 2020-05-07 | | Release date: | 2021-11-17 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states.
Nat Commun, 13, 2022
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1O7E
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1H8Y
 | | Crystal structure of the class D beta-lactamase OXA-13 in complex with meropenem | | Descriptor: | (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, BETA-LACTAMASE, SULFATE ION | | Authors: | Pernot, L, Frenois, F, Rybkine, T, L'Hermite, G, Petrella, S, Delettre, J, Jarlier, V, Collatz, E, Sougakoff, W. | | Deposit date: | 2001-02-17 | | Release date: | 2001-07-12 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of the Class D B-Lactamase Oxa-13 in the Native Form and in Complex with Meropenem
J.Mol.Biol., 310, 2001
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1N4O
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1H8Z
 | | Crystal structure of the class D beta-lactamase OXA-13 | | Descriptor: | BETA-LACTAMASE, SULFATE ION | | Authors: | Pernot, L, Frenois, F, Rybkine, T, L'Hermite, G, Petrella, S, Delettre, J, Jarlier, V, Collatz, E, Sougakoff, W. | | Deposit date: | 2001-02-17 | | Release date: | 2001-07-12 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structures of the Class D B-Lactamase Oxa-13 in the Native Form and in Complex with Meropenem
J.Mol.Biol., 310, 2001
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3ZKB
 | | CRYSTAL STRUCTURE OF THE ATPASE REGION OF Mycobacterium tuberculosis GyrB WITH AMPPNP | | Descriptor: | DNA GYRASE SUBUNIT B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Agrawal, A, Roue, M, Spitzfaden, C, Petrella, S, Aubry, A, Volker, C, Mossakowska, D, Hann, M, Bax, B, Mayer, C. | | Deposit date: | 2013-01-22 | | Release date: | 2013-09-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Biochem.J., 456, 2013
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3ZM7
 | | CRYSTAL STRUCTURE OF THE ATPASE REGION OF Mycobacterium tuberculosis GyrB WITH AMPPCP | | Descriptor: | DNA GYRASE SUBUNIT B, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | | Authors: | Agrawal, A, Roue, M, Spitzfaden, C, Petrella, S, Aubry, A, Volker, C, Mossakowska, D, Hann, M, Bax, B, Mayer, C. | | Deposit date: | 2013-02-05 | | Release date: | 2013-09-18 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Biochem.J., 456, 2013
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3ZKD
 | | CRYSTAL STRUCTURE OF THE ATPASE REGION OF Mycobacterium tuberculosis GyrB WITH AMPPNP | | Descriptor: | DNA GYRASE SUBUNIT B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Agrawal, A, Roue, M, Spitzfaden, C, Petrella, S, Aubry, A, Volker, C, Mossakowska, D, Hann, M, Bax, B, Mayer, C. | | Deposit date: | 2013-01-22 | | Release date: | 2013-09-18 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Biochem.J., 456, 2013
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1W79
 | | Crystal structure of the DD-transpeptidase-carboxypeptidase from Actinomadura R39 | | Descriptor: | D-alanyl-D-alanine carboxypeptidase, MAGNESIUM ION, SULFATE ION | | Authors: | Sauvage, E, Herman, R, Petrella, S, Duez, C, Frere, J.M, Charlier, P. | | Deposit date: | 2004-08-31 | | Release date: | 2005-06-28 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins.
J. Biol. Chem., 280, 2005
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3BFF
 | | class A beta-lactamase SED-G238C complexed with faropenem | | Descriptor: | (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid, (5R,6S)-6-(1-hydroxyethyl)-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, Class A beta-lactamase Sed1, ... | | Authors: | Pernot, L, Petrella, S, Sougakoff, W. | | Deposit date: | 2007-11-21 | | Release date: | 2007-12-18 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | acyl-intermediate structures of the class A beta-lactamase SED-G238C
To be Published
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1W8Q
 | | Crystal Structure of the DD-Transpeptidase-carboxypeptidase from Actinomadura R39 | | Descriptor: | COBALT (II) ION, D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, SULFATE ION | | Authors: | Sauvage, E, Herman, R, Petrella, S, Duez, C, Frere, J.M, Charlier, P. | | Deposit date: | 2004-09-24 | | Release date: | 2005-06-28 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Crystal Structure of the Actinomadura R39 Dd-Peptidase Reveals New Domains in Penicillin-Binding Proteins.
J.Biol.Chem., 280, 2005
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1W8Y
 | | Crystal structure of the nitrocefin acyl-DD-peptidase from Actinomadura R39. | | Descriptor: | (2R)-2-{(1R)-2-OXO-1-[(2-THIENYLACETYL)AMINO]ETHYL}-5,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC ACID, D-alanyl-D-alanine carboxypeptidase, MAGNESIUM ION, ... | | Authors: | Sauvage, E, Herman, R, Petrella, S, Duez, C, Frere, J.M, Charlier, P. | | Deposit date: | 2004-10-01 | | Release date: | 2005-06-28 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal Structure of the Actinomadura R39 Dd- Peptidase Reveals New Domains in Penicillin- Binding Proteins.
J.Biol.Chem., 280, 2005
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