1B6U
CRYSTAL STRUCTURE OF THE HUMAN KILLER CELL INHIBITORY RECEPTOR (KIR2DL3) SPECIFIC FOR HLA-CW3 RELATED ALLELES
Summary for 1B6U
| Entry DOI | 10.2210/pdb1b6u/pdb |
| Descriptor | P58 KILLER CELL INHIBITORY RECEPTOR (1 entity in total) |
| Functional Keywords | killer cell inhibitory receptor, natural killer cell, hla, major histocompatibility complex class i (mhc class i), cell surface receptor, immunoglobulin superfamily |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 28189.14 |
| Authors | Maenaka, K.,Juji, T.,Stuart, D.I.,Jones, E.Y. (deposition date: 1999-01-18, release date: 1999-01-27, Last modification date: 2024-11-20) |
| Primary citation | Maenaka, K.,Juji, T.,Stuart, D.I.,Jones, E.Y. Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I. Structure Fold.Des., 7:391-398, 1999 Cited by PubMed Abstract: T cells and natural killer (NK) cells perform complementary roles in the cellular immune system. T cells identify infected cells directly through recognition of antigenic peptides that are displayed at the target cell surface by the classical major histocompatibility complex (MHC) class I molecules. NK cells monitor the target cell surface for malfunction of this display system, lysing potentially infected cells that might otherwise evade recognition by the T cells. Human killer cell inhibitory receptors (KIRs) control this process by either inhibiting or activating the cytotoxic activity of NK cells via specific binding to MHC class I molecules on the target cell. PubMed: 10196125DOI: 10.1016/S0969-2126(99)80052-5 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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