1FDS

HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 COMPLEXED WITH 17-BETA-ESTRADIOL

Summary for 1FDS

Entry DOI	10.2210/pdb1fds/pdb
Descriptor	17-BETA-HYDROXYSTEROID-DEHYDROGENASE, ESTRADIOL (3 entities in total)
Functional Keywords	dehydrogenase, 17-beta-hydroxysteroid
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14061
Total number of polymer chains	1
Total formula weight	35246.33
Authors	Housset, D.,Breton, R.,Mazza, C.,Fontecilla-Camps, J.-C. (deposition date: 1996-06-28, release date: 1997-02-12, Last modification date: 2024-04-03)
Primary citation	Breton, R.,Housset, D.,Mazza, C.,Fontecilla-Camps, J.C. The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors. Structure, 4:905-915, 1996 Cited by PubMed Abstract: The steroid hormone 17beta-estradiol is important in the genesis and development of human breast cancer. Its intracellular concentration is regulated by 17beta-hydroxysteroid dehydrogenase, which catalyzes the reversible reduction of estrone to 17beta-estradiol. This enzyme is thus an important target for inhibitor design. The precise localization and orientation of the substrate and cofactor in the active site is of paramount importance for the design of such inhibitors, and for an understanding of the catalytic mechanism. PubMed: 8805577 DOI: 10.1016/S0969-2126(96)00098-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation