3TDL
Structure of human serum albumin in complex with DAUDA
Summary for 3TDL
| Entry DOI | 10.2210/pdb3tdl/pdb |
| Descriptor | Serum albumin, MYRISTIC ACID, 11-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)undecanoic acid (3 entities in total) |
| Functional Keywords | protein-drug complex, human serum albumin, myristate, dauda, fluorescent fatty acid analogue, protein binding, transport protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P02768 |
| Total number of polymer chains | 1 |
| Total formula weight | 68353.89 |
| Authors | |
| Primary citation | Wang, Y.,Luo, Z.,Shi, X.,Wang, H.,Nie, L.,Huang, M. A fluorescent fatty acid probe, DAUDA, selectively displaces two myristates bound in human serum albumin Protein Sci., 20:2095-2101, 2011 Cited by PubMed Abstract: 11-(Dansylamino) undecanoic acid (DAUDA) is a dansyl-type fluorophore and has widely used as a probe to determine the binding site for human serum albumin (HSA). Here, we reported that structure of HSA-Myristate-DAUDA ternary complex and identified clearly the presence of two DAUDA molecules at fatty acid (FA) binding site 6 and 7 of HSA, thus showing these two sites are weak FA binding sites. This result also show that DAUDA is an appropriate probe for FA site 6 and 7 on HSA as previous studied, but not a good probe of FA binding site 1 that is likely bilirubin binding site on HSA. PubMed: 21997768DOI: 10.1002/pro.749 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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