5SIV

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH C(c2cc1c(nccn1)cc2)(=O)NCc3cccs3, micromolar IC50=>10

Summary for 5SIV

Entry DOI	10.2210/pdb5siv/pdb
Group deposition	To be published (G_1002229)
Descriptor	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	159088.96
Authors	Joseph, C.,Benz, J.,Flohr, A.,Brunner, M.,Rudolph, M.G. (deposition date: 2022-02-01, release date: 2022-10-12, Last modification date: 2024-10-16)
Primary citation	Flohr, A.,Schlatter, D.,Kuhn, B.,Rudolph, M.G. Crystal Structure of a human phosphodiesterase 10 complex To be published,
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation