8SMQ
Crystal Structure of the N-terminal Domain of the Cryptic Surface Protein (CD630_25440) from Clostridium difficile.
Summary for 8SMQ
| Entry DOI | 10.2210/pdb8smq/pdb |
| Descriptor | hypothetical protein CD630_25440, CHLORIDE ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
| Functional Keywords | center for structural biology of infectious diseases (csbid), structural genomics, center for structural genomics of infectious diseases, csgid, cd630_25440, unknown function |
| Biological source | Clostridioides difficile 630 |
| Total number of polymer chains | 4 |
| Total formula weight | 81777.45 |
| Authors | Minasov, G.,Shuvalova, L.,Brunzelle, J.S.,Kiryukhina, O.,Wawrzak, Z.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID),Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2023-04-26, release date: 2023-05-10, Last modification date: 2023-12-06) |
| Primary citation | Alexander, L.T.,Durairaj, J.,Kryshtafovych, A.,Abriata, L.A.,Bayo, Y.,Bhabha, G.,Breyton, C.,Caulton, S.G.,Chen, J.,Degroux, S.,Ekiert, D.C.,Erlandsen, B.S.,Freddolino, P.L.,Gilzer, D.,Greening, C.,Grimes, J.M.,Grinter, R.,Gurusaran, M.,Hartmann, M.D.,Hitchman, C.J.,Keown, J.R.,Kropp, A.,Kursula, P.,Lovering, A.L.,Lemaitre, B.,Lia, A.,Liu, S.,Logotheti, M.,Lu, S.,Markusson, S.,Miller, M.D.,Minasov, G.,Niemann, H.H.,Opazo, F.,Phillips Jr., G.N.,Davies, O.R.,Rommelaere, S.,Rosas-Lemus, M.,Roversi, P.,Satchell, K.,Smith, N.,Wilson, M.A.,Wu, K.L.,Xia, X.,Xiao, H.,Zhang, W.,Zhou, Z.H.,Fidelis, K.,Topf, M.,Moult, J.,Schwede, T. Protein target highlights in CASP15: Analysis of models by structure providers. Proteins, 91:1571-1599, 2023 Cited by PubMed Abstract: We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology. PubMed: 37493353DOI: 10.1002/prot.26545 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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